Thursday, November 29, 2012

Simple measures cut infections caught in hospitals

(AP) ? Preventing infections from surgery is a major concern for hospitals and it turns out some simple measures can make a big difference.

A project at seven big hospitals reduced infections after colorectal surgeries by nearly one-third. It prevented an estimated 135 infections, saving almost $4 million.

The measures included having patients shower with special germ-fighting soap before surgery, and having surgery teams change gowns, gloves and instruments during operations to prevent spreading germs picked up during the procedures.

Practices were standardized at the seven hospitals.

The Joint Commission hospital regulating group and the American College of Surgeons directed the project. They announced results on Wednesday.

___

Online:

Joint Commission: http://www.jointcommission.org

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-11-28-Hospital-Linked%20Infections/id-cbc939d14ab34ab09466524ecf451686

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'Chill-coma' recovery: Cold cricket case could defrost mysteries of changing climate

ScienceDaily (Nov. 28, 2012) ? Biologists from Western University have discovered that insects recover from chill-coma by getting water and salt back where it belongs. These findings, published online today by Proceedings of the National Academy of Sciences (PNAS), not only identify the very mechanisms that drive insect movement at low temperatures but will lead to a better understanding of agriculture management, biodiversity and climate change.

Wildlife photographers often pose insects by cooling them down in a refrigerator, where they enter a paralyzed state called chill-coma. Insects in chill-coma appear dead, but are still very much alive. If the shutterbug is patient, he or she will witness the bug as it awakens. Chill-coma was first noted more than a century ago and photographers are not the only ones who have found use for it.

Many alpine spiders prey on insects that have inadvertently landed on snowfields and have gone into a chill-coma while biologists, like Western professor Brent Sinclair and his PhD student Heath MacMillan, use chill-coma recovery as a way to measure insect cold tolerance. A research team, led by MacMillan, studied recovery from chill-coma in fall field crickets and found that recovery depends on fixing the water and salt imbalances that materialize when the insect is cold.

"Insects lose the ability to maintain proper water balance in the cold so when they are chilled, water and sodium move from the insect blood, called hemolymph, into their gut," says MacMillan. "This is bad for the insect because it concentrates potassium in the blood that remains, which leaves muscles unable to function."

To get their muscles working again, crickets restore normal hemolymph potassium concentration, which can occur in a matter of minutes. But just because the insect can move, which MacMillan notes is useful when insects don't wish to be eaten, doesn't mean its physiology has returned to normal.

"Crickets still need to restore sodium and water balance," explains MacMillan. "We measured the metabolic cost of this reboot and found that the process increased a cricket's metabolic rate by as much as 50 per cent for a few hours."

"This work is significant because it allows us to identify the mechanisms that drive insect movement at low temperatures," adds Sinclair. "This will lead to a better understanding of the biology of pest and beneficial insects during cold snaps at any time of year, and maybe help us to predict how different insects respond to changing conditions. This will also help us manage agriculture and biodiversity in a changing climate."

This research was supported by the Natural Sciences and Engineering Research Council of Canada and the Canadian Foundation for Innovation.

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The above story is reprinted from materials provided by Western University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. H. A. MacMillan, C. M. Williams, J. F. Staples, B. J. Sinclair. Reestablishment of ion homeostasis during chill-coma recovery in the cricket Gryllus pennsylvanicus. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1212788109

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/rWIIFQF59YQ/121128122543.htm

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Wednesday, November 28, 2012

Brad Pitt: Fatherhood Has Made Me a Better Man | Celeb Baby ...

It has been a wild year for Brad Pitt. He has 6 kids to juggle, a busy acting career and he finally is engaged to Angelina Jolie.

While promoting his most recent film, Killing Them Softly, he recently sat down to talk about what has been happening in his life and upon reflection he tells the latest issue of People Magazine that:

?It?s been a?family type of year, a down-home type of year?

Angelina, or ?mama? as he calls her, has worked more which means that he spent more time than usual on daddy-duty. It?s a job that the actor has come to really enjoy because it makes him be less selfish and focus on others.

Has fatherhood made him a better man?

?Absolutely,? Pitt says. Being a dad ?takes you right off yourself.?

As for the much anticipated wedding, he said the couples main plan is to ?Keep it simple. Keep it simple ? really.?

Do you think he and Angie will ever really tie that knot? I suspect he is ready, but she seems to always find a reason to postpone exchanging those vows!

Also in the latest issue of People you?ll find all the details on that bloody Thanksgiving brawl at Halle Berry?s house that left fiance, Olivier Martinez needing medical attention and baby-daddy, Gabriel Aubry holding a restraining order. All the ugliness stems from that dragged out custody battle over little Nahla. Halle requested that the court allow her to move to France with the girl and when her request was denied, Gabriel insists that she is now trying more drastic measures to cut him out of Nahla?s life.

Source: http://celebbabylaundry.com/2012/11/brad-pitt-fatherhood-has-made-me-a-better-man/

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Big winners share lessons, risks of Powerball win

COLUMBIA, Mo. (AP) ? So you just won the $500 million Powerball jackpot, the second highest in lottery history. Now what?

Perhaps it's time for a tropical vacation or a new car. There are bills to pay, loans to settle, debts to square.

Past winners of mega-lottery drawings and financial planners have some more sound advice: Stick to a budget, invest wisely, learn to say no and be prepared to lose friends while riding an emotional roller-coaster of joy, anxiety, guilt and distrust.

"I had to adapt to this new life, "said Sandra Hayes, 52, a former child services social worker who split a $224 million Powerball jackpot with a dozen co-workers in 2006, collecting a lump sum she said was in excess of $6 million after taxes. "I had to endure the greed and the need that people have, trying to get you to release your money to them. That caused a lot of emotional pain. These are people who you've loved deep down, and they're turning into vampires trying to suck the life out of me."

The single mother kept her job with the state of Missouri for another month and immediately used her winnings to pay off an estimated $100,000 in student loans and a $70,000 mortgage. She spent a week in Hawaii and bought a new Lexus, but six years later still shops at discount stores and lives on a fixed income ? albeit, at a higher monthly allowance than when she brought home paychecks of less than $500 a week.

"I know a lot of people who won the lottery and are broke today," she said. "If you're not disciplined, you will go broke. I don't care how much money you have."

Lottery agencies are keen to show off beaming prize-winners hugging oversize checks at celebratory news conferences, but the tales of big lottery winners who wind up in financial ruin, despair or both are increasingly common.

There's the two-time New Jersey lottery winner who squandered her $5.4 million fortune. A West Virginia man who won $315 million a decade ago on Christmas later said the windfall was to blame for his granddaughter's fatal drug overdose, his divorce, hundreds of lawsuits and an absence of true friends.

The National Endowment for Financial Education cautions those who receive a financial windfall ? whether from lottery winnings, divorce settlements, cashed-out stock options or family inheritances ? to plan for their psychological needs as well as their financial strategies. The Denver-based nonprofit estimates that as many as 70 percent of people who land sudden windfalls lose that money within several years.

"Being able to manage your emotions before you do anything sudden is one of the biggest things," said endowment spokesman Paul Golden. "If you've never had the comfort of financial security before, if you were really eking out a living from paycheck to paycheck, if you've never managed money before, it can be really confusing. There's this false belief that no matter what you do, you're never going to worry about money again."

David Gehle, who spent 20 years at a Nebraska meatpacking plant before he and seven ConAgra Foods co-workers won a $365 million Powerball jackpot in 2006, used some of his winnings to visit Australia, New Guinea and Vietnam. He left ConAgra three weeks after he won, and now spends his time woodworking and playing racquetball, tennis and golf.

But most of his winnings are invested, and the 59-year-old still lives in his native Lincoln. He waited for several years before buying a $450,000 home in a tidy neighborhood on the southern edge of town.

"My roots are in Nebraska, and I'm not all that much different now than I was before," Gehle said. "I'm pretty normal. I never was the kind of guy who went for big, expensive cars or anything like that. I just want something that runs."

In the first year after he won, Michael Terpstra would awaken many nights in a panic. Had he slept in? Was he late to work the night shift?

"At times I'd wake up and this would all seem like a dream," the 54-year-old said. "I'd have to walk around the house and tell myself, I did win. I'm not working anymore, and I do live here. I didn't get drunk, break into someone's house and go to sleep. This is where I'm supposed to be."

His new home is a roomy, two-story house in south Lincoln with a big-screen television and paintings of Jesus on the walls. He no longer uses alarm clocks and spends his days taking his 92-pound black lab, Rocco, on walks.

He was terrified when he first won, convinced that he would lose all of the money and have to return to work. So he lives carefully off the interest from conservative investments, with help from accountants and lawyers. He bought the new house and a truck, but struggles to name any extravagant purchases.

"I can't buy a super yacht. I can't buy a Gulfstream," he said. "Then again, I don't think I'd use either one, so why would I buy one?"

That said, some mega-winners still can't resist the lure of big jackpots, at least not the two-buck chances. On Tuesday, former ConAgra worker Dung Tran, a Vietnamese immigrant, walked into the same Lincoln U-Stop where he purchased the winning ticket six years ago and bought 22 more from the very employee who sold him the first prize-winner, said cashier Janice Mitzner.

"We joked about it," she said. "I told him, 'Wouldn't it be something if you won again?'"

Hayes is also hoping to strike rich again ? she bought 10 tickets at a Dirt Cheap liquor store on her way home Tuesday while speaking with an Associated Press reporter. Unlike many big winners, she has kept a visible public profile instead of going underground, appearing on a 2007 reality TV show ("Million Dollar Christmas"), writing an online Life After the Lottery blog and self-publishing a short book, "How Winning the Lottery Changed My Life."

"We have this drawing tomorrow, and if somebody wins, God bless them," she said. "They're going to need those blessings."

___

Alan Scher Zagier can be reached at http://twitter.com/azagier

___

Associated Press writers Grant Schulte in Lincoln, Neb., and Josh Funk in Omaha contributed to this report.

Source: http://news.yahoo.com/big-winners-share-lessons-risks-powerball-win-081059542.html

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Tuesday, November 27, 2012

Wall Street isn't backing Jack Lew for Treasury - The Term Sheet ...

jack-lew

Jack Lew

FORTUNE -- Jack Lew, the frontrunner to be named Treasury Secretary in Obama's second term, isn't Wall Street's first choice for the key economic post. He's not even its second.

"I've talked to a bunch of investors and it's seen as a net negative going from [Tim] Geithner to Lew," says Chris Krueger, senior political analyst at Guggenheim Partners. "Who does Wall Street want? Not Jack Lew."

Lew,?57, spent three years on Wall Street working at Citigroup (C) as the chief operating officer of its alternative asset investment management unit. One of the funds Lew's group invested in was run by John Paulson, who at the time was betting heavily against the housing markets and banks. But that's not the part of Lew's resume that anyone seems to remember. And it's certainly not the important part.

MORE: Fiscal Cliff: A modest proposal

After Lew, a Queens, New York native, graduated from Harvard University and Georgetown Law, he headed straight to Washington and has mostly stuck inside the Beltway ever since. He's been on teams credited with brokering major budget deals. He worked for Tip O'Neill when the House speaker struck a deal to raise taxes and cut benefits with President Reagan. And Lew was a key member of President Clinton's budget team, which simultaneously erased the deficit and struck a long-term deal with Republicans to preserve entitlements.

Under Obama, Lew served as the head of the Office of Budget and Management, and a year ago he became Obama's chief of staff.

Since the election Obama has seemingly been trying to patch things up with Wall Street, which threw its collective support behind Romney. After the election, Obama called JPMorgan Chase (JPM) CEO Jamie Dimon and other business leaders. And Lew recently met with Dimon to talk about the fiscal cliff. Geithner is expected to exit the Treasury job early next year.

Nonetheless, some financial executives say that if Obama were to choose Lew for Treasury Secretary, it would signal that the president is not as serious about mending his relationship with corporate leaders as he says. Wall Streeters say the two other candidates who are considered in the mix for the job, former investment banker and two-time second Erskine Bowles and BlackRock (BLK) CEO Larry Fink, would be preferable to Lew. Bowles has been a deficit hawk, and Fink clearly knows the debt market. What's more, unlike Lew, neither one would need an introduction to Wall Street.

MORE: How Tim Geithner can dodge the next debt crisis

Don Marron, a dean of Wall Street who was also once rumored to be a top pick for the Treasury Secretary job (under a Bob Dole presidency in 1996), says he doesn't know Lew, or where he stands on business issues. And Marron?says that will be a problem for corporate America and the market. "Lew will be more of an unknown at a time when you don't want unknown," he says.

Strangely enough, Democrats don't seem so excited about Lew either. They don't think he will be tough enough on Wall Street. And by picking Lew, who has little background in regulating financial markets, Obama would signal that he is more focused right now on striking a budget deal, and less focused on further tinkering with the rules on Wall Street.

Lew wouldn't be the first Treasury Secretary to come from more of a political background instead of Wall Street or corporate America. James Baker, for instance, served as the Treasury Secretary during Reagan's second term.?But the relationship between the Treasury Secretary and Wall Street matters more than it used to. One of the legacies of Tim Geithner, who is a lifetime regulator, has been to focus the position more on market regulation. The Treasury Secretary is now the head of the Financial Stability Oversight Council, the newly formed team of regulators that is supposed to be on the lookout for risks that could cause future crises. And the relationship between the economy and the market's performance is much closer than it was back in Baker's day.

So some of this can be dismissed as more Masters of the Universe griping they are not being heard by Obama. But not all of it.

Source: http://finance.fortune.cnn.com/2012/11/26/jack-lew-treasury-secretary/

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To Stop House Foreclosure or Not? ? Real Estate | Raw Business Law

business_law.jpg

It?s an epidemic that hasn?t been seen since the great depression; houses are being foreclosed at three times the normal rate in some counties across America. As a result of this sudden rise in foreclosures a new type of business has sprung up within the real estate market called the ?short sell.? If you are considering bankruptcy or foreclosure it is extremely important to understand this practice that helps and hinders many at the same time.

Have you seen the ads that say ?stop house foreclosure? online, in your mailbox and on billboards? Chances are these are make-shift investors offering to negotiate a short sell in lieu of foreclosure for you. A short sell is when an uninterested party negotiates with your mortgage company for a lower payoff for your home instead of foreclosure. Most of the times these people are looking to ?scoop up? cheap houses or they already have an investor/buyer lined up to buy the home. The end result is that you have to move or rent from the investor.

When banks foreclose it?s rarely a profitable situation for them, very rare in today?s market. Most often the properties are in disrepair, dirty and littered with unwanted household items. The bank has to clean, repair and then discount the home to put it on the market. After the discounts, repairs, appraisers, real estate commissions and other added expenses banks are usually losing around 35% of the amount that was owed by the homeowner. This is why a lot of banks are using the short sell option more often as their foreclosure departments are maxed out to capacity.

Short sell experts simply attempt to handle all of the aforementioned headaches and skip to the discounted price. The person that negotiates the short sell will either make money by having the house pre-sold for a higher price than they negotiate or will be keeping the property as an investment and renting it. Either way they stand to earn a nice profit and while helping their clients circumvent foreclosure. If you are significantly behind on your mortgage and cannot see the light of day this may be a good avenue for you depending on your particular situation.

There are a few things you need to be aware of before executing a short sell to stop house foreclosure. The first thing is to know is if you are considering bankruptcy you definitely want to seek advice from council before executing a short sell. Selling property for a loss can sometimes be considered income by the trustee and complicate the bankruptcy. Also, if your primary goal is to avoid foreclosure to preserve your credit, it may not matter whether the bank forecloses or not. If you fall four months behind (120 days) on your mortgage this is considered to be a foreclosure by all mortgage lenders regardless of the fact.

According FHA loan requirements, borrowers must be out of a foreclosure for three years with little or no negative marks since the foreclosure to be approved for a new mortgage. If after three years you can prove adequate income, that you have established new credit and manage a 3% down payment you will almost certainly be approved for a new home. So if homeowners look at foreclosure from a three year perspective the picture is not quite so gloomy if they plan ahead and manage their finances well. In certain situations it becomes a viable option for many people in today?s housing market.

Your home is an investment; businesses cut their losses on bad investments every day as a cost of doing business. If you bought a home for $200k with little or no money down within the last 5 years chances are that you still owe somewhere around $195k on the home. If you are in an area where property values have dropped significantly you may find yourself upside down in your home. For example, you may still owe $195k on your home and it?s only worth $175k on the market. When this happens you need to look at the reality of the situation much as a business would and consider cutting your losses.

Consider this, if you are $20k upside down in the market and behind on payments, how long will it take you to catch up on your payments and at what cost? More than that, how long will it take for your house value to catch up with what you owe on it? Will you have to refinance to get out of a bad mortgage and what costs will be associated with this? By all estimations today it may take 3 years to 5 years for the housing market to catch up with today?s losses and regain momentum. In Japan?s case it took ten years when they went through a similar crisis.

A very likely scenario is that in three years you will owe exactly what your house is worth and still not have any equity in your home. In housing markets like we are in rental houses are cheap and plentiful. In fact, in Atlanta $300k homes are renting for roughly half of the cost of what that mortgage would be. If you were to accept a foreclosure and move to a rental home of equal value you could likely cut your home expenditure in half. If you were to save the difference between the payments for three years you would have a nice down payment for a new home. According to FHA loan requirements, as of today, you would be able to buy a home.

In closing, the point of this article is not to encourage foreclosure but to demystify it. Foreclosure is bad for you, the lender, and the economy. However, treading water on a bad investment for the sake of good credit or avoiding the stigma of foreclosure doesn?t make sense. In three years time you will most likely be able to buy the same home you are in now and have a lower note with more equity. Banks and businesses cut their losses on bad investments everyday while planning for their next venture, you can as well.

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Source: http://rawbusinesslaw.com/2012/11/26/to-stop-house-foreclosure-or-not-real-estate/

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Monday, November 26, 2012

Black Friday sales slip as shoppers opt for Thursday ?doorbusters?

Security guards break up a fight between shoppers outside a Bowling Green, Ky., Target, Nov. 22, 2012. (AP)

Black Friday, the official kickoff to the holiday shopping season, saw more foot traffic than ever before, according to estimates. But it appears so-called "doorbuster" deals offered the day before dinged sales.

According to ShopperTrak, which tracks retail foot traffic, there were more than 307 million store visits on Friday, up 3.5 percent. But Black Friday shoppers spent an estimated $11.2 billion, down 1.8 percent over 2011, when consumers spent $11.4 billion.

And for once, the sluggish economy is not to blame.

"It is all Black Thursday's fault," ZeroHedge.com said.

[Slideshow: Black Friday madness]

Shopping malls were "less hectic" on Black Friday this year, Bloomberg.com reported, as retailers "have turned Black Friday, once a one-day event after Thanksgiving, into a week's worth of deals and discounts."

And Thursday's deals "attracted some of the spending that's usually meant for Friday," ShopperTrak said.

Big box stores like Wal-Mart and Target were open on Thanksgiving night, drawing crowds that were--in some cases--rowdy. (Thankfully, it was nothing like the dystopian version of shopping hell recently envisioned by "Saturday Night Live.")

Another reason for the Black Friday dip: people skipped lines and shopped online. According to IBM Benchmark, online sales rose 17 percent on Thanksgiving and 21 percent on Black Friday.

Source: http://news.yahoo.com/blogs/lookout/black-friday-sales-slip-shoppers-opt-thursday-doorbusters-165525323--finance.html

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Dating other people while in a relationship - Talk About Marriage


General Relationship Discussion Although anyone can post anywhere on Talk About Marriage, this section is for people interested in general relationship and marriage advice.


Old Yesterday, 09:25 AM ? #6 (permalink)

Member

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Join Date: Apr 2012

Location: The Most DANGEROUS City in America!

Posts: 1,266


Quote:

Is there something wrong with this scenario?
Allow me to translate LiarSpeak for you, Costa.

Quote:

He told me he would like to settle down when he is sure that we are truly right for each other
"I would like to settle for you when I am done chasing anyone else who attracts my attention; and when I am sure I can't get anyone hotter than you. You are my Plan B."

Quote:

meanwhile I am free to date anyone I like.
"I don't value you enough to want to be exclusive with you, so don't get the wrong idea that you're 'special', because you're not. But I'd still like to fvck you when I can!"

There you go; now that you've removed the forked-tongue, double-speak, it's really quite clear (and quite simple), isn't it?

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Old Yesterday, 03:53 PM ? #13 (permalink)

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Join Date: Apr 2012

Location: Kansas City Metro area

Posts: 1,139


Quote:

If you are looking for a relationship with more substance, keep sex off of the table for a while with the next guy until you are more exclusive.

I can't agree with this point. I've found that sex is one of the important ways a man decides whether a woman is worth being with. Bad sex will equal a quick fade even after they've become exclusive.

Plus, people fall for people who are "into" them. Withholding sex for some arbitrary point is just a way of saying, "I'm not that into you."

As one of the five pillars of compatibility, I would encourage you to do whatever feels natural to you sexually, but remain aware that you are still learning about areas that you are or are not compatible on.

I have to articles on my blog related to this topic that can help you decide how long you should or shouldn't wait:

How Soon Should You Have Sex in a New Relationship?

5 Pillars of Compatibility (& Incompatibility)

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Old Yesterday, 04:03 PM ? #14 (permalink)

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Join Date: Sep 2012

Posts: 151


Quote:

I can't agree with this point. I've found that sex is one of the important ways a man decides whether a woman is worth being with. Bad sex will equal a quick fade even after they've become exclusive.

Plus, people fall for people who are "into" them. Withholding sex for some arbitrary point is just a way of saying, "I'm not that into you."

As one of the five pillars of compatibility, I would encourage you to do whatever feels natural to you sexually, but remain aware that you are still learning about areas that you are or are not compatible on.

I disagree with the above bolded part. I didn't have sex with my husband prior to marriage, not because I wasn't into him, but because of a vow that I made not only to myself, but to my faith. It was hard, and we crossed some lines, but didn't have sex. Now of course this is not true for everyone, but I disagree that it says that you're not into them.

I do think that when sex is not on the table at the beginning you can filter through what a person is like, and if you are compatible in other areas.nsex can cloud emotions for some.

I have not read your articles yet but looking forward to reading them later.

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Source: http://talkaboutmarriage.com/general-relationship-discussion/61606-dating-other-people-while-relationship.html

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Sunday, November 25, 2012

Daily Kos: In 400 Days the Health Insurance Cliff will Kick In. For Real.

It's actually not too complicated. A couple multiplications and subtractions (and there's a table just below if you don't care to follow the math). The law says that if you, as an individual, make between 300% and 400% of the federal poverty level, the Federal government will provide a tax credit for any premiums you pay for standard insurance bought on the exchanges in excess of 9.5% of your income. But if you make more than 400% of federal poverty level, no tax credit will be available. (The astute reader may have just figured out the problem.)

The Federal Poverty Level (FPL) in most states is $11,170. Four hundred percent of that is $44680. Nine and a half percent of that is $4245. Suppose you are paying $500/month in premiums for your health insurance (not a particularly high rate if you are an older person but not yet eligible for Medicare) or $6000/year. Assuming you are eligible for the subsidy, then in 2014 the Federal government will effectively pay $1755 of that (the excess above $4245), and you will only have to pay $4245.

But what if you make $44681? Now you make more than four hundred percent of the Federal poverty level. Now the federal government will pay nothing -- $0.00 -- to help you with your health insurance premiums; you will have to pay it all. You just fell over a $1754 cliff.

Who, you might ask, could have written such a stupid law? That's a good question. Unfortunately, I don't have a good answer. Congress.

If you make If you pay You'll get But if you make You'll get
$44680 individually $6000/yr in premiums $1755 in subsidies $44681 individually $0 in subsidies
$14856 individually $4000/yr in premiums $3703 in subsidies $14857 individually $3554 in subsidies
$88200 as a family of 4 $15000/yr in premiums $6621 in subsidies $88201 as a family of 4 $0 in subsidies
What will this mean? As far as I can tell, it will mean that a bunch of people are going get shafted. Some will have no idea they've been shafted, and the rest of them are going to be very upset when they realize how they've been shafted.

A lot of people simply don't know exactly how much they will have made in a given year until it's over and it's too late. Maybe you get that $10 you didn't think about in interest from your savings account and it pushes you over the limit, or one of your clients pays you a few days early, or your non-health-insurance-providing company gives you a $100 Christmas bonus... and suddenly you're over the limit. Your boss getting into the Christmas spirit has cost you $1500 or more. Imagine a million people suddenly realizing that if they had made a hundred dollars less they would have made a thousand dollars more...

The effect is most severe at the top, but the cliff doesn't just apply at the top end of the subsidy range (400% of FPL). If you make 133% of FPL the government will pay the cost of your premiums beyond 2% of your income. But if you make 134% of FPL the government will only the pay the cost of your premiums beyond 3% of your income. ?So if you make $14856 and your insurance premiums are $4000/yr the government would pay $3703, but if you make $14857 the government will pay only $3554, about a $150 difference. Which, if you're making less than $15000 a year, is nothing to shrug off.

Photobucket

It gets worse if you're a family. Much, much worse. The FPL for a family of four is $22,050. Four times that is $88,200. Nine and a half percent of that is $8379. A family of four could easily spend $15,000 on insurance premiums, so the federal government would pick up $6621 of that. But if the wage earners in the famiy make a dollar more, $88,201... then SPLAT -- the family has just lost more than $6000.

So be careful come December 31st, 2014 -- do you really want to pick up that $1 bill you see lying on the sidewalk?

Income Level ( % of FPL ) Max Premium as % of Income
Less than 133% 2% of Income
133% - 150% 3% - 4% of income
150% - 200% 4% - 6.3% of income
200% - 250% 6.3% - 8.05% of income
250% - 300% 8.05% - 9.5% of income
300% - 400% 9.5% of income

Kaiser Foundation: EXPLAINING HEALTH CARE REFORM: ?Questions About Health Insurance Subsidies.

Source: http://www.dailykos.com/story/2012/11/25/1164534/-In-400-Days-the-Health-Insurance-Cliff-will-Kick-In-For-Real

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PFT: NFL could change red-flag rule during season

sb-barnesAP

At at time when plenty of teams seem to be unable or unwilling to spot concussions until the game in which the injury was sustained is over, the Giants are in the small minority of teams that take extra steps to identify whether a player needs to be evaluated after taking a blow to the head.

?[T]he athletic trainers are spread out over the field, the doctors are spread out on the field, and so we?re now communicating through earpieces and radios,? Giants head trainer and senior V.P. of medical services Ronnie Barnes told Steve Serby of the New York Post. ??We?re being ? I?d like to say more vigilant ? in looking at the field, and making sure we?re not missing anything. ?We alert each other that we?ve seen something, and I think that?s been very helpful.?

Barnes said that perhaps four or five teams use that many people to spot possible concussions.

?[I]t?s been really helpful to me because I?m not running back and forth, because I can be down working with a player, and another player could go down,? Barnes said.

And when the Giants think someone may have suffered a concussion, the Giants don?t mess around with a cursory sideline exam performed in the elements and the noise and the confusion of the sidelines.

?Generally speaking, if we decide that a player has been concussed or has concussion symptoms, we take them inside,? Barnes said. ?And inside, we have an iPad, with a sideline assessment tool, which then documents all of the symptoms within minutes after they were removed from the field, and it also includes a balance test, which then we can look at during the week, to say, ?This is where he was during the game, and this is where he is on Thursday, on Friday, on Saturday.??

It?s a great approach. ?It?s the right approach. ?So the question now becomes why aren?t the other 27 or 28 teams doing the same thing?

While we completely agree with the NFLPA?s repeated requests for the use of independent neurologists during games, the biggest challenge for the NFL when it comes to concussions is striking the balance between removing from play those who has suffered concussions while also not removing from action during a key stretch of a game a player who ultimately is deemed to be fine.

?I?m a caretaker of the game with respect to sports medicine, because of Wellington Mara, and because we?re a flagship team in this league,? Barnes said, ?and I think it?s our responsibility to continue to be flagship, not only on the field, but in medicine.?

It?s not the product of a recent epiphany. ?Barnes explained that the Giants always have been ahead of the curve when it comes to concussions.

?I?d like to think that we?ve always had here at the Giants a high level of suspicion for concussion, and that we were conservative,? Barnes said. ??Lawrence Taylor, we actually used to hide his helmet when he got concussed. And he?d be looking for his helmet. Anybody who had a concussion, we would take their helmet so they couldn?t return to the game.?

If the current approach is good enough for the team that has won two of the last five Super Bowls, it should be good enough for everyone else. ?The NFL should study the Giants? approach, and the NFL should make it mandatory for every other team.

Source: http://profootballtalk.nbcsports.com/2012/11/23/after-detroit-debacle-nfl-could-change-red-flag-rule-during-season/related/

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Scuba diver, drowned in Fla., was research star

MIAMI (AP) ? A diver from New Mexico who died in a Thanksgiving Day boating accident was a manager at one of the nation's leading research laboratories who was in Florida for a holiday dive trip with her nephew, authorities said Friday.

An autopsy was planned Friday for Nina Poppelsdorf, 54, who was part of a group of about two dozen coming back from a dive outing Thursday when a large wave flipped over their 45-foot catamaran.

The Sandia Park, New Mexico, woman died at a hospital after the Coral Princess capsized, said Broward Sheriff's Office spokeswoman Dani Moschella. Witnesses said the boat was approaching the Hillsboro Inlet in Pompano Beach when a wave 8 to 10 feet high came in and flipped the twin-hulled craft upside down.

Poppelsdorf was in Florida with her nephew, who is from Pennsylvania, just for the dive trip.

"They just went on this fun trip together to just do dives," Moscehlla said. "So this is especially tragic that it was on Thanksgiving and it ended in tragedy."

Poppelsdorf was a senior manager of the radiation protection, industrial hygiene and safety center at Sandia National Laboratories, lab spokeswoman Heather Clark said. She was hired in Aug. 1992 at the lab, a federal research and development center.

"Nina worked for about 20 years at Sandia National Laboratories and made many contributions to industrial hygiene, safety and radiation protection," said Sandia Environment, Safety & Health director Sid Gutierrez, her supervisor. "She served as both a staff member and later as an outstanding manager. She was recently promoted to senior manager and was well-respected by her peers and staff alike. Her contributions to improving safety at Sandia are numerous and she will be missed as both a member of the Sandia family and as a wonderful person."

Darrell Fong, a Sandia Labs safety engineering manager who worked with Poppelsdorf, said she was admired for her professionalism and easily identified by her laugh.

"She had a great laugh. Everyone could recognize her laughter. They'd say 'Oh, there's Nina.'" Fong said.

Poppelsdorf was a leader of a Sandia team that helped in the response to the crisis at Japan's Fukushima nuclear plant after the March 2011 earthquake and tsunami left several reactors there without cooling water, Fong said. He also said Poppelsdorf was a certified diving instructor.

The Coral Princess is a Corinthian catamaran owned by South Florida Diving Headquarters in Pompano Beach. A phone message left Friday by The Associated Press for the owner of the boat was not immediately returned.

Three of the 23 people on the boat were treated and released. Most of them were from out of town on vacation, authorities said

Officials said nearby boaters jumped into the water to pull people to safety. Pompano Beach Fire Rescue workers used personal watercraft to get to the site. The U.S. Coast Guard and other state and local agencies assisted in the rescue.

The accident remains under investigation.

___

Associated Press writer Bob Christie in Phoenix, Ariz., contributed to this story.

Source: http://news.yahoo.com/mexico-woman-dies-fla-dive-boat-capsizes-112843586.html

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Saturday, November 24, 2012

Black Friday Liveblog: Walmart early opening draws big crowds (+video)

Walmart took flak for opening on Thanksgiving Day, but initial reports suggest shoppers came in droves.?

By Monitor Staff / November 22, 2012

Shoppers wait in line for the 8 p.m. opening of the Times Square Toys-R-Us store in the lead-up to Black Friday, on Thursday, Thanksgiving Day, 2012, in New York.

John Minchillo/AP

Enlarge

Updated 3:30 a.m.

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' + google_ads[0].line2 + '
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'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // --> After hours and sometimes days of waiting, Los Angeles shoppers inaugurate Black Friday at several stores.

If you're a savvy Black Friday shopper, you've studied the layout of the stores you want to shop days before the event. You've scouted out the most efficient way to get the items you want and get to the checkout line.

You may have even gone online to look at store layouts, which are even available on Google Maps. (Check it out with the store you're in, or click here to see the store then click on the marker and zoom in to see the layout of a Best Buy in Compton, Calif.)

But now that you're standing in line for checkout, does anything look different? Take a look around (that is, if you can see anything with all those 60-inch TVs sitting in people's shopping carts).

You may notice that the store looks less cluttered. Maybe the aisles are wider. ?That's what stores do when anticipating a rush of customers, such as on Black Friday. They tweak the store's layout.

Here's the tweaking jcpenney has done for Black Friday:

Along with holiday d?cor incorporating jcpenney?s?button campaign, each jcpenney store features a refreshed presentation this season:

  • Racks have less merchandise, are featured side-by-side and have been moved 18 inches away from the aisle, offering a cleaner and less cluttered presentation.
  • Color blocking is used across departments to create strong merchandise statements.
  • Brands and prices are prominently highlighted while sitting/resting areas have also been added throughout the store.

"We know that the first thing on our customers? holiday shopping lists is a convenient, hassle-free shopping experience," writes jcpenney spokeswoman Sarah Holland in an e-mail. "Team members throughout the store will be equipped with mobile checkout devices, giving customers a fast and easy way to complete their credit card purchases so that they can spend less time in line. As part of this service, customers also have the option of having their receipt e-mailed to them."

At Walmart, they "make the flow smoother," says one knowledgeable observer. "They staff up appropriately. There are a lot of people out in the red shirts that are big-event staffs, making sure folks are in line."

Online stores also staff up to anticipate the rush of orders. This year, for example, Amazon is hiring 50,000?seasonal?workers to help fulfill customer orders, an Amazon spokeswoman writes in an e-mail.

Of course, all that tweaking doesn't eliminate long lines and delays at the store ? or even sometimes online.

Updated Friday 1:55 a.m.

Two minutes before the doors opened on Black Friday at the Walmart store in Framingham, Mass., whoops went up from the hundreds of shoppers waiting in a line that snaked out into the parking lot.

It was that way at Walmart stores across the country.

"WalMart looking like a #Zoo! Every parking spot is full!" tweeted Atlanta resident Antonio Citty Eagle.

"You can't tell that this line wraps around four aisles for a 10:00 PM sale on televisions," tweeted Andrew Grossman of Portland, Ore.

Walmart's controversial strategy of opening at 8 p.m. on Thanksgiving Day in most of its stores around the United States seemed to be paying off. "

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/0fLB8MgRJQE/Black-Friday-Liveblog-Walmart-early-opening-draws-big-crowds-video

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Thursday, November 22, 2012

Health, Wellness and Fitness | Dayton City Paper

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Monday, November 19, 2012

The 10 Best Low Risk Investments for High Return

best low risk investments with high returnThe first time I stood at the top of the high dive at the rec center pool, I was a nervous wreck.

I never realized how afraid of heights I was until that moment.

For many that have never invested before, they feel this same apprehensive feeling.

With the rising cost of living, it?s imperative that we invest (preferably with the lowest risk possible) to generate high yield returns.

High rates of return on your investments are wonderful because it means you don?t have to invest as much capital to reach your investing goals. Yet the higher return you want the more risk you take to get that return.

As you near or enter retirement (or if you are managing investments for your high school senior?s college fund) your appetite for risk drops?precipitously. You simply cannot afford to see a huge drop in the market right before the time you need to begin withdrawing funds from the investment accounts.

Instead, you need to shift to low risk investments. These types of investments will generate a lower return because you aren?t taking as much risk, but you?re okay with that. At this time capital preservation is more important that astronomical growth rates. You need to know your account won?t drop 25% in a year and severely impact your investing goals.

Best Low Risk Investments

When it comes to investing even those targeting low risk, low return investments will face a wide array of options that can be confusing. Here are a few of your best low risk investment options for your portfolio.

1. Certificates of Deposit

There is nothing more boring than a Certificate of Deposit. You can get it through your bank, credit union, or even through your investment broker.

With a Certificate of Deposit (CD) you trade depositing your money for a specific length of time to a financial institution.

In return you get a set interest rate for that period of time that will not change, no matter what happens to interest rates. You are locked in until maturity of the term length. (You can choose to withdraw from the CD early for a penalty that is equal to 3 months? worth of interest, usually.)

Why are CDs at the top of our best low risk investment list? Because as long as you get a certificate of deposit with an FDIC insured financial institution you are guaranteed to get your principal back as long as your total deposits at that specific financial institution are less than $250,000. The government is guaranteeing you cannot have a loss, and the financial institution will give you some interest on top of that. How much interest you earn is dependent on the length of the CD term and interest rates in the economy. Interest rates are low, but if you lock in your money for many years you can get a little bit more interest.

Earn a risk-free return on your cash with a Certificate of Deposit. You can open a CD with great interest rates with?CIT Bank, Ally Bank, and Capital One 360?(formerly ING Direct).

2. Treasury Inflation Protected Securities (TIPS)

The US Treasury has several types of bond investments for you to choose from.

One of the lowest risk is called Treasury Inflation Protection Securities or TIPS. These bonds come with two methods of growth.

The first is a fixed interest rate that doesn?t change for the length of the bond. The second is built-in inflation protection that is guaranteed by the government. Whatever rate inflation grows during the time you hold the TIPS, your investment?s value will rise with that inflation rate.

For example, you might invest in a TIPS today that only comes with a 0.35% interest rate. That?s less than certificate of deposit rates and even basic online savings accounts. That isn?t very?enticing?until you realize that if inflation grows a 2% per year for the length of the bond then your investment value will grow with that inflation and give you a much higher return on your investment.

TIPS can be purchased individually or you can invest in a mutual fund that in turn invests in a basket of TIPS. The latter option makes managing your investments easier while the former gives you the ability to pick and choose with specific TIPS you want.

Want to protect your portfolio from inflation? Purchase TIPS through a great broker like Scottrade or E*TRADE.

3. Money Market Funds

?A money market fund is a mutual fund with the main purpose of not losing any value of your investment.

The fund also tries to pay out a little bit of interest as well to make parking your cash with the fund worthwhile. The fund?s goal is to maintain a Net Asset Value (NAV) of $1 per share.

These funds aren?t foolproof, but do come with a strong pedigree in protecting the underlying value of your cash. It is possible for the NAV to drop below $1, but it is rare.

4. Municipal Bonds

When a government at the state, or local needs to borrow money they don?t use a credit card. Instead, the government entity issues a municipal bond. These bonds, also known as munis, are except from Federal income tax at the very least. Most states and local municipalities also exempt income tax on these bonds, but talk to your accountant before making any decisions.

What makes municipal bonds so safe? Not only do you avoid income tax (which means a higher return compared to an equally risky investment that is taxed) but the likelihood of the borrower defaulting is very low. There have been some enormous municipality bankruptcies in recent years, but this is very rare. Governments can always raise taxes or issue new debt to pay off old debt, which makes holding a municipal bond a pretty safe bet.

5. US Savings Bonds

US Savings Bonds are similar to Treasury Inflation Protected Securities because they are also backed by the United States Federal government. The likelihood of default on this debt is microscopic which makes them a very stable investment.

There are two main types of US Savings Bonds: Series I and Series EE.

Series I bonds consist of two components: a fixed interest rate return and an adjustable inflation-linked return. They are somewhat similar to TIPS because they have the inflation adjustment as part of the total return. The fixed rate never changes, but the inflation return rate is adjusted every 6 months and can also be negative (which would bring your total return down, not up).

Series EE bonds just have a fixed rate of interest that is added to the bond automatically at the end of each month (so you don?t have to worry about reinvesting for compounding purposes). Rates are very low right now, but there is an interesting facet to EE bonds: the Treasury guarantees the bond will double in value if held to maturity (which is 20 years). That equates to approximately a 3.5% return on your investment. If you don?t hold to maturity you will only get the stated interest rate of the bond minus any early withdrawal fees. (Another bonus to look into: if you use EE bonds to pay for education, you might be able to exclude some or all of the interest earned from your taxes.)

Looking to purchase some Series I or Series EE Bonds? You can do that directly through TreasuryDirect.gov.

6. Annuities

Annuities are a point of contention for some investors because shady financial advisors have over-promoted them to individuals where the annuity wasn?t the right product for their financial goals. They don?t have to be scary things; annuities can be a good thing to help stabilize your portfolio over a long period of time.

But be aware and talk with a good financial advisor first: annuities are very complex financial instruments with lots of catches built into the contract.

There are several types of annuities, but at the end of the day when you purchase an annuity you are making a trade with an insurance company. They?re taking a lump sum of cash from you. In return they are giving you a stated rate of guaranteed return. Sometimes that return is fixed (with a fixed annuity), sometimes that return is variable (with a variable annuity), and sometimes your return is dictated in part by how the stock market does and gives you downside protection (with an equity indexed annuity).

If you are getting a form of guaranteed return your risk is a lot lower. Unlike the backing of the Federal government, your annuity is backed by the insurance company the holds it (and perhaps another company that further insurers the annuity company). Nonetheless your money is typically going to be very safe in these complicated products.

7. Cash Value Life Insurance

Another controversial investment is cash value life insurance. This insurance not only pays out a death benefit to your beneficiaries when you die (like a term life insurance policy), but also allows you to accrue value with an investment portion in your payments. Whole life insurance and universal life insurance are both types of cash value life insurance.

While term life insurance is by far a cheaper option, it only covers your death. One of the best perks of using cash value life insurance is the accrued value can not only be borrowed against throughout your life, but isn?t hit with income tax. It is a clever way to pass some value onto your heirs without either side being hit with income tax.

Some Middle Risk Investments to Consider

If you don?t want to go ?all in? on the riskiest class of assets you can still generate higher returns by taking a few steps in that direction. Here are a few investments to consider to add a bit more risk to your portfolio.

8. Dividend Paying Stocks and Mutual Funds

One of the easiest ways to squeeze a bit more return out of your stock investments is simply to target stocks or mutual funds that have nice dividend payouts. If two stocks perform exactly the same over a given period of time, but one has no dividend and the other pays out 3% per year in dividends, then the latter stock would be a better choice.

Of course picking individual stocks isn?t easy (use some of the trading tools at Scottrade or E*TRADE to help you target dividend stocks) and comes with risk that the company may falter and take your investment down with it. A safer bet would be to invest money into a dividend stock mutual fund. With this type of mutual fund the fund company targets stocks that pay nice dividends and does all of the work for you. You also get diversification so that one or two stocks can?t tank your entire investment.

9. Preferred Stock

Adding on to the dividend stock theme is preferred stock. Preferred stock is a type of stock that companies issue that has both an equity (stock) portion and a debt portion (bond). In the?hierarchy?of payouts to forms of investments, preferred stock sits between bond payments (which come first) and common stock dividends (which come last).

Preferred stock are not traded nearly as heavily as common stock, but do have less risk than the common stock. It is just another way to own shares in a company while getting dividend payments.

10. Peer to Peer Lending

P2P Lending is a completely different type of investment. Instead of buying shares in a company (and its future profits) you are lending your money to someone else in hopes they will pay you back. This makes peer to peer lending risky if you screen poorly because if you fund a terrible loan, you might not get your money back.

On the other hand if you screen well then you can earn some really nice returns. Thankfully, P2P lending companies have worked to offer screening tools and portfolio settings for your investment gain. Instead of having to go through every single loan (which you can still do) they offer an option to where you target a certain rate of return and the company lends out money to a portfolio for you.

One thing to be extremely aware of when lending money to strangers on the internet is how well the company?s collection process is. Lending Club in particular has done a great job in setting up their collection practices in order to protect their investors. (Lend Academy did a great interview with LC?s Head of Collections.)

Related Posts with Thumbnails

Source: http://www.goodfinancialcents.com/low-risk-investments-options-high-yield/

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01.00>> Watch Now Jacksonville State vs No. 6 Florida Live Streaming Online NCAA Football 2012

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Microsoft announces SkyDrive SDKs for .NET and Windows Phone 8, highlights ? ? Engadget

Microsoft announces SkyDrive SDKs for .NET and Windows Phone 8, highlights ?
Engadget
After the introduction of new APIs last year, Microsoft has released SkyDrive SDKs for almost every major platform including Windows 8, JavaScript Web library, Android and iOS. Now the cloud service has opened its doors to more of Microsoft's own with new ?
Windows 8 tablets need more apps, but OS will eventually outpace Android, SAP ?Computerworld
SkyDrive Gets Selective Sync, Easier SharingPC Magazine
Microsoft updates SkyDrive with selectable folder sync and updated apps for ?Connected Digital World (blog)

all 47 news articles??

Source: http://theglobalvillageweb.com/news/microsoft-announces-skydrive-sdks-for-net-and-windows-phone-8-highlights-engadget/

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Thursday, November 15, 2012

Cancer therapy: Nanokey opens tumors to attack

ScienceDaily (Nov. 14, 2012) ? There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.

Many types of tumor form a compact mass, like the phalanx formation of Greek antiquity. And although many drugs are known to be toxic to cancer cells, they are often unable to percolate into the inner recesses of the tumor. Upon intravenous administration, for instance, cytotoxic drugs may only be able to penetrate the outermost layers of a solid tumor. A team led by LMU pharmacologist Dr Manfred Ogris has now developed a new type of gene delivery vehicle, which is designed to open up a route through the vascular network that supplies the tumor so that drugs can reach their target.

Large tumors need a local blood supply for continued growth, and are capable of inducing the formation of new vessels. The resulting vasculature is more permeable than normal vessels, which should facilitate the delivery of cytotoxins. However, the lymphatic system does not work optimally in tumors, and back-pressure associated with the build-up of lymph limits the diffusion of drugs. As it happens, the cytokine Tumor Necrosis Factor ? (TNF?), which can kill tumor cells directly, is able to increase blood vessel permeability as part of its pro-inflammatory function.

Shielding the organism from the drug

TNF? is already being used in combination with chemotherapeutic agents for the treatment of muscle tumors in arms and legs, but in this case, the local vasculature must be cut off surgically. "Unfortunately, therapeutically effective amounts of TNF? cannot be administered systemically, because this would lead to activation of, and damage to, all the vessels in the organism," says Ogris. "For this reason, it is not possible to use this approach on tumors in internal organs or against dispersed metastases."

A new strategy employing gene therapy could provide a solution to this problem. The idea is to deliver the gene for TNF? directly and specifically to the tumor cells. If this worked, the tumor cells themselves could produce and secrete the cytokine, ensuring that its local concentration becomes sufficiently high to permeabilize the blood vessels only in the immediate vicinity of the tumor. "We first designed a version of the TNF? gene that allows for the production of large amounts of the protein," Dr. Baowei Su, first author on the study, explains.

Shielding the drug from the organism

In collaboration with researchers at the Technische Universit?t M?nchen and the Helmholtz Center Munich, the LMU team constructed a form of the gene which, in contrast to the normal version, is unlikely to induce non-specific inflammation. The plasmid was then incorporated into special nanoparticles, which not only protect the DNA from inactivation during its journey through the bloodstream, but also allow it to be targeted to the tumor. Experiments carried out on cell cultures confirmed that tumor cells treated with these particles synthesize large amounts of TNF?.

Treatment with the loaded nanoparticles alone, however, had only a moderate effect on tumor cells, but when they were administered in combination with the DNA-intercalating drug doxorubicin, the impact on tumor cell growth was markedly enhanced. Under the trade name Doxil, doxorubicin, which inhibits DNA replication, is available in a liposome-encapsulated form. Incorporating the drug into liposomes of 100 nm in diameter reduces side-effects and increases its half-life in the circulation, making it more effective than unencapsulated formulations.

No evidence for drug resistance

When mice with neuroblastoma, or mice that had received a xenograft of a human liver tumor, were first exposed to nanoparticles carrying the TNF? gene and subsequently treated with Doxil the researchers observed, in real time, that the drug became concentrated in the tumor tissue. Indeed, in some cases, the combination was sufficient to bring tumor growth to a standstill, even in animals that had already undergone three cycles of treatment. This finding suggests that drug resistance, which often limits the efficacy of chemotherapy, does not develop in this context.

In addition to eliminating the primary tumor, a successful therapy must be able to kill metastatic tumors in other tissues. When the researchers looked at mice with neuroblastoma, or mice carrying implanted human colon tumors that had metastasized to the liver, they found that the new treatment strategy also significantly reduced the growth of metastases. "TNF? might also be useful in combination with other agents and other treatment regimens," says Ogris. "We now plan to optimize our gene delivery system, and hope that we can soon begin to plan preclinical tests of the new approach."

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Story Source:

The above story is reprinted from materials provided by Ludwig-Maximilians-Universit?t M?nchen.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Baowei Su, Arzu Cengizeroglu, Katarina Farkasova, Joana R. Viola, Martina Anton, Joachim W. Ellwart, Rudolf Haase, Ernst Wagner, Manfred Ogris. Systemic TNF? Gene Therapy Synergizes With Liposomal Doxorubicine in the Treatment of Metastatic Cancer. Molecular Therapy, 2012 DOI: 10.1038/mt.2012.229

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/g3PU9pDSRAo/121114113803.htm

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Europe Is On Strike As Its Economy Continues To Implode, Stock ...

If May Day is when Europe celebrates labor and jobs (if any), November 14 is its opposite, bizarro cousin as today Europe wakes up to a dead(er than usual) economy. The reason: virtually every European country is on strike. From BusinessWeek: "Spanish workers staged a second general strike this year as unions across Europe prepared the biggest coordinated protests yet against budget cuts that policy makers say are needed to end the region?s debt crisis. In Spain, unions said most auto and metal workers joined the strike, even as power demand was just 13 percent below usual. One of Portugal?s two biggest labor groups also called a strike, partial walkouts are planned in Greece and Italy, and French unions are urging workers to join protest marches. ?This is a strike against the suicidal economic policies of the government,? Ignacio Fernandez Toxo, head of Spain?s CCOO union, told supporters late yesterday." In other words, Europe's economy which is already doing swimmingly, is about to see 1/60th of its Q4 GDP removed as virtually no economic goods or services are produced today.

And speaking of "swimmingly", the Greek economy shrank 7.2% in the third quarter from a year earlier, the Greek statistics authority said on Wednesday in its first estimate for the period. The authority said Greece, in its fifth year of recession, contracted further than the 6.3 percent 12-month recession posted for the second quarter of 2012. In other words, the economic contraction accelerated in the quarter ended September 30.

Elsewhere, "Euro-area industrial production dropped the most in more than three years in September, led by double-digit declines in Portugal and Ireland. Output in the 17-nation euro area fell 2.5 percent from August, when it increased 0.9 percent, the European Union?s statistics office in Luxembourg said today. Economists had projected a drop of 2 percent, according to the median of 35 estimates in a Bloomberg News survey. From a year earlier, September output slumped 2.3 percent. European companies are struggling to maintain sales and earnings as the euro-area economy weakens under pressure from the fiscal crisis and faltering global growth." In other words, the whole world is slowly grinding to an economic halt, and people in the socialist continent celebrate by striking, coming soon to an America near you.

In other news, the IMF said that it wants a "real fix, not a quick fix? in Greece. "Speaking during a visit to Malaysia, Lagarde said that all of Greece's partners shared the same goal of putting the country's recovery programme back on track. "All partners share the same objectives and the same concerns, in other words (that) Greece is ... returned to economic stability, can reaccess markets as soon as possible," Lagarde told reporters. "Obviously from the IMF's perspective, we expect a real fix, not a quick fix, and that means clearly debt that is sustainable as quickly as possible." So... what the IMF has been doing in Greecefor the past 3 years, that was a "real fix"?

Concluding today's bad news rout from Europe was the UK, where jobless claims rose more than expected as the labor market slowed, the BoE cut the UK outlook and warned of a risk of "persistent low growth", and Germany auctioned off its first negative yield bond since July.

All in all, one can see why equity futures are on fire.

/sarc

The full recap from Deutsche Bank

One week on from the US Presidential election result, and we?re no closer to a solution on the fiscal cliff with 48 days left in the year. According to White House Press Secretary Jay Carney, Obama will begin budget negotiations by calling for $1.6trn in additional tax revenue over the next decade, double the $800 billion discussed in talks with GOP leaders during the summer of 2011 (which ultimately fell apart). The seemingly hardline approach sets the scene for tough negotiations with congressional leaders on Friday. The President has called a press conference today where he is likely to provide more detail on the aforementioned tax revenue increases which are reported to include raising taxes on corporations and allowing tax cuts to expire for top income earners (Washington Post, WSJ).

In terms of the markets, a late sell-off in US equities led by technology stocks (-0.90%) marked an otherwise quiet day. The S&P500 closed -0.4% lower, after shedding 0.65% in the final hour of the session. This took us to the lowest level since August 2nd. President Obama?s tweet, in the final hour of trading, that "I'm committed to solving our fiscal challenges. But I refuse to accept any approach that isn't balanced? didn?t help markets hoping for a more conciliatory tone, but probably summed up the state of play of negotiations thus far. US 10yr treasury yields closed at 1.594%, slipping back below the 1.60% mark, and threatening to break out of the 1.6% to 1.8% trading range that has held since August.

Ahead of today?s FOMC minutes, Fed vice-chair Janet Yellen commented that the Fed is considering tying Fed policy to inflation and unemployment targets. Yellen added that the Fed has a target jobless rate range of 5.2% to 6% and that employment targeting may mean that the Fed will tolerate a temporary deviation from inflation ranges. If such a policy comes to pass this is quite a big deal and would need even more money creation.

Asian markets are relatively mixed overnight with gains seen on the Hang Seng (+0.85%) and Nikkei (+0.2%) but the Shanghai Composite (-0.25%) and KOSPI (--0.1%) are underperforming. China?s current President Hu Jintao declared the 18th national party congress officially over today. All eyes are on the final makeup of the Politburo Standing Committee, the highest decision making body of the Party, which will be unveiled tomorrow. Markets are hoping for a substantial representation of reform-minded members. The latest power data in China showed electricity consumption rising 6.1% yoy in October, up from September?s low of 2.9%yoy, providing incremental confidence to some on the trajectory of the Chinese economy. The benchmark Asian IG credit index is trading flat while the Australian dollar is trading marginally higher (0.1%) against the greenback.

Over in Europe, the Stoxx600 closed 0.79% higher led by gains in the peripheries (IBEX +1.66%, MIB +1.4%). Most of the gains came late in the session on the latest Greek headlines suggesting that the troika is bundling the next 3 disbursements for Greece into one payment (totalling more than EUR44bn). However investors were (once again) disappointed later in the US session as German FM Schauble and Greek PM Samaras both said the idea was only being discussed at this stage.

Schauble added that while it was ?logical? to combine disbursements, control mechanisms were needed to ensure that Greece keeps to reforms. 10-year Spanish bond yields rose 7.5bp at one point yesterday (to just under 6%) before rallying to close 4bp lower at 5.85%, helped by a re-run of reports that a Spanish bailout is imminent.

Turning to the day ahead, the main focus will be on the FOMC minutes which may provide more detail on policy options following the end of Operation Twist next month. We may also get more detail on Yellen?s inflation/employment targeting plans. In terms of data, US? retail sales and the BoE?s inflation report are the main economic releases. Reuters is reporting that Spanish, Portuguese, Greek and Italian unions have planned a coordinated ?European Day of Action and Solidarity?, with strikes against austerity policies. Obama?s press conference is scheduled for 1:30pm US EST today, after which the president will meet with a number of business leaders to discuss his budget proposals.

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Source: http://www.zerohedge.com/news/2012-11-14/europe-strike-its-economy-continues-implode-stock-futures-highs

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